关于普尔纳克对苯并(a)芘诱导的人淋巴细胞染色体损伤的化学保护作用的体外研究。
In vitro studies on chemoprotective effect of Purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes.
作者信息
Ghaisas S D, Bhide S V
机构信息
Swami Prakashananda Ayurvedic Research Centre, Bombay, India.
出版信息
Cell Biol Int. 1994 Jan;18(1):21-7. doi: 10.1006/cbir.1994.1003.
Human lymphocytes were used as an assay system to test chemopreventive activity of natural products. Purnark, a mixture of extracts of turmeric, betel leaf and catechu, was tested for its chemoprotective activity against BP induced DNA damage. Sister chromatid exchange and micronuclei were used as markers to assess the protective activity of Purnark. Purnark gave 50-60% protection against BP induced SCEs and micronuclei. Purnark at 100 micrograms dose did not show any genotoxicity.
人类淋巴细胞被用作检测系统来测试天然产物的化学预防活性。Purnark是姜黄、槟榔叶和儿茶提取物的混合物，被测试其对苯并芘诱导的DNA损伤的化学保护活性。姐妹染色单体交换和微核被用作评估Purnark保护活性的标志物。Purnark对苯并芘诱导的姐妹染色单体交换和微核有50%-60%的保护作用。100微克剂量的Purnark未显示任何遗传毒性。
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