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[经皮肾镜取石术的麻醉及围手术期重症监护的经验积累。结石及肾盂输尿管连接部异常的内镜治疗现状]

[Acquired experience in anesthesia and perioperative intensive care in percutaneous nephrolithotomy. Current approach in the endoscopic treatment of lithiasis and pyelo-ureteral junction anomalies].

作者信息

Artagnan J, Milon D, Corbel L, Le Nestour M, Conduche P, Guille F, Cipolla B, Staerman F, Labrador J, Lobel B

机构信息

Service Urologie, Centre Hospitalo-Universitaire Pontchaillou, Rennes.

出版信息

Prog Urol. 1994 Feb;4(1):56-62.

PMID:8186795
Abstract

Percutaneous endoscopic treatment of the kidney retains a place in the treatment of renal stones (percutaneous nephrolithotomy--PCNL) and ureteropelvic junction abnormalities (endopyeloplasty). It requires anaesthesia ensuring surgical comfort and safety for the patients despite changes in position and the prolonged ventral supine position. The operation carries certain iatrogenic risks related to caliceal irrigation in patients with more or less documented episodes of infection and carries risks of haemorrhage and effraction of adjacent organs. 282 patients treated by PCNL between 1984 and 1991 were reviewed in order to define the respective indications for general anaesthesia and peridural anaesthesia and to determine the modalities, to evaluate the risk and severity of absorption of irrigation fluid and to assess the risk of infection by defining the indications for prophylactic antibiotics. General anaesthesia, using etomidate and propofol via an infusion pump, ensures surgical comfort, anaesthetic safety and better control of intraoperative complications. The renewed interest in this technique must be counterbalanced by the growing incidence of anaphylactic reactions related to anaesthetic drugs. Operations lasting more than 2 hours, raised intracaliceal pressure, the initially exclusive use of glycine for irrigation induce haemodilution complications, possibly aggravated by glycine intoxication. Repeated surgery is preferable with the use of an Amplatz tube as often as possible and physiological saline, except when required by the operation. Patients with a history of urinary tract infection or infected stones should receive prolonged and effective antibiotics before, during and after the operation. Prophylactic antibiotics are reserved for those patients with no history of infection. These principles equally apply to percutaneous nephrolithotomy and endopyeloplasty.

摘要

经皮肾镜治疗在肾结石治疗(经皮肾镜取石术——PCNL)及肾盂输尿管连接部异常(内镜肾盂成形术)中仍占有一席之地。尽管患者体位会发生改变且需长时间仰卧位,但该治疗仍需麻醉以确保患者手术时的舒适度和安全性。该手术存在一定医源性风险,对于或多或少有感染发作记录的患者,与肾盏冲洗相关,还存在出血及邻近器官穿孔的风险。对1984年至1991年间接受PCNL治疗的282例患者进行回顾,以明确全身麻醉和硬膜外麻醉各自的适应证,确定手术方式,评估冲洗液吸收的风险和严重程度,并通过明确预防性抗生素的适应证来评估感染风险。使用依托咪酯和丙泊酚经输液泵进行全身麻醉,可确保手术舒适度、麻醉安全性并更好地控制术中并发症。与麻醉药物相关的过敏反应发生率不断上升,必须对该技术重新产生的兴趣加以权衡。手术持续时间超过2小时、肾盏内压力升高、最初仅使用甘氨酸进行冲洗会引发血液稀释并发症,甘氨酸中毒可能会使其加重。尽可能使用安普瑞尔导管和生理盐水进行重复手术,除非手术有特殊要求。有尿路感染病史或结石感染的患者在手术前、手术期间和手术后应接受长时间有效的抗生素治疗。预防性抗生素仅用于无感染病史的患者。这些原则同样适用于经皮肾镜取石术和内镜肾盂成形术。

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