Herdman S J, Sandusky A L, Hain T C, Zee D S, Tusa R J
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
J Vestib Res. 1994 Spring;4(1):71-80.
Postural stability in patients with bilateral vestibular deficits from aminoglycoside toxicity was characterized by examining their ability to use different sensory cues to maintain balance and by recording their automatic postural responses to sudden translational and rotational (pitch) perturbations of the support surface. We found our patients had increased sway on sensory tests in which either visual or somatosensory cues were altered and were unable to maintain their balance when both visual and somatosensory cues were altered compared to age-matched normal subjects. The amount of vestibular loss, as inferred from the VOR Tc, accounted for a significant amount of A-P sway on test 4 in which somatosensory cues were altered. The frequency response of anterior-posterior sway in the BVL group suggests that they use more hip movements than do normal subjects to maintain postural stability. The responses of BVL patients to sudden translations of the support surface did not differ from those of normal subjects. More BVL patients lost their balance, however, on the initial trial of the toes-up rotational perturbation of the support surface than did normal subjects.
通过检查双侧前庭功能因氨基糖苷类药物毒性受损患者利用不同感觉线索维持平衡的能力，以及记录他们对支撑面突然平移和旋转（俯仰）扰动的自动姿势反应，对其姿势稳定性进行了表征。我们发现，与年龄匹配的正常受试者相比，在视觉或体感线索改变的感觉测试中，我们的患者摇摆增加，并且当视觉和体感线索都改变时，他们无法维持平衡。从视动反射时间常数推断出的前庭损失量，在体感线索改变的测试4中，占前后摇摆的很大比例。双侧前庭功能丧失组前后摇摆的频率响应表明，与正常受试者相比，他们使用更多的髋部运动来维持姿势稳定性。双侧前庭功能丧失患者对支撑面突然平移的反应与正常受试者没有差异。然而，在支撑面脚趾向上旋转扰动的初始试验中，更多的双侧前庭功能丧失患者比正常受试者失去平衡。
