Troncoso J C, Costello A, Watson A L, Johnson G V
Department of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
Brain Res. 1993 Jun 11;613(2):313-6. doi: 10.1016/0006-8993(93)90918-d.
Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.
成对螺旋丝（PHF）是阿尔茨海默病（AD）特有的异常神经元聚合物。尽管tau蛋白似乎是PHF的主要成分，但tau蛋白聚合或整合到PHF中的机制仍不清楚。在此，我们表明体外牛tau蛋白的氧化会导致该蛋白明显二聚化并聚合成丝状物。这些观察结果表明，体内tau蛋白的氧化可能有助于AD患者中PHF的形成。
