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铁蛋白与进行性核上性麻痹中存在的异常tau细丝相关。

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

作者信息

Pérez M, Valpuesta J M, de Garcini E M, Quintana C, Arrasate M, López Carrascosa J L, Rábano A, García de Yébenes J, Avila J

机构信息

Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Spain.

出版信息

Am J Pathol. 1998 Jun;152(6):1531-9.

PMID:9626057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1858430/
Abstract

Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.

摘要

从进行性核上性麻痹（PSP）患者大脑中纯化出含tau蛋白的细丝，并对其进行了分离和表征。这些细丝与通过生物物理和生化方法鉴定为铁蛋白壳的规则颗粒共同纯化。在体内，PSP患者大脑中的tau蛋白积累与铁蛋白共定位。这些结果表明，铁蛋白/铁可能调节PSP中tau蛋白聚集体的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/ceb8eca162b7/amjpathol00018-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/bc3039148d5d/amjpathol00018-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/1ab7aac288e1/amjpathol00018-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/f574132d70d1/amjpathol00018-0135-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/d4413ef6e2ed/amjpathol00018-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/ceb8eca162b7/amjpathol00018-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/bc3039148d5d/amjpathol00018-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/1ab7aac288e1/amjpathol00018-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/f574132d70d1/amjpathol00018-0135-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/d4413ef6e2ed/amjpathol00018-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a7/1858430/ceb8eca162b7/amjpathol00018-0137-a.jpg

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本文引用的文献

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PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA.进行性核上性麻痹。一种涉及脑干、基底神经节和小脑的异质性变性，伴有垂直凝视和假性延髓麻痹、颈部肌张力障碍和痴呆。
Arch Neurol. 1964 Apr;10:333-59. doi: 10.1001/archneur.1964.00460160003001.
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Role of glycosaminoglycans in determining the helicity of paired helical filaments.糖胺聚糖在决定双螺旋丝螺旋度中的作用。
Am J Pathol. 1997 Oct;151(4):1115-22.
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Redox Biol. 2025 Feb;79:103478. doi: 10.1016/j.redox.2024.103478. Epub 2024 Dec 19.
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