Pérez M, Valpuesta J M, de Garcini E M, Quintana C, Arrasate M, López Carrascosa J L, Rábano A, García de Yébenes J, Avila J
Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Spain.
Am J Pathol. 1998 Jun;152(6):1531-9.
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.
从进行性核上性麻痹（PSP）患者大脑中纯化出含tau蛋白的细丝，并对其进行了分离和表征。这些细丝与通过生物物理和生化方法鉴定为铁蛋白壳的规则颗粒共同纯化。在体内，PSP患者大脑中的tau蛋白积累与铁蛋白共定位。这些结果表明，铁蛋白/铁可能调节PSP中tau蛋白聚集体的形成。
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