Silva L C, Fontes M A, Campagnole-Santos M J, Khosla M C, Campos R R, Guertzenstein P G, Santos R A
Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Brain Res. 1993 Jun 11;613(2):321-5. doi: 10.1016/0006-8993(93)90920-i.
In this study, we determined the cardiovascular effects produced by micro-injection of the heptapeptide Angiotensin-(1-7) [Ang-(1-7)] into the rat ventrolateral medulla (VLM). Micro-injection of Ang-(1-7) into the rostral VLM and the caudal pressor area of the VLM produced significant increases in arterial pressure, comparable to that observed with micro-injection of Ang II. The changes in arterial pressure were associated with more variable changes in heart rate (HR) (usually tachycardia). On the other hand, micro-injection of Ang-(1-7) into the caudal depressor area induced decreases in arterial pressure and HR. The results suggest that, besides Ang II, Ang-(1-7) is involved in the mediation of the cardiovascular actions of the renin-angiotensin system in the VLM.
在本研究中，我们测定了向大鼠延髓腹外侧区（VLM）微量注射七肽血管紧张素 -（1 - 7）[Ang -（1 - 7）]所产生的心血管效应。向VLM头端和VLM尾侧升压区微量注射Ang -（1 - 7）可使动脉压显著升高，与微量注射Ang II时观察到的情况相当。动脉压的变化与心率（HR）更具变异性的变化相关（通常为心动过速）。另一方面，向VLM尾侧降压区微量注射Ang -（1 - 7）可导致动脉压和HR降低。结果表明，除了Ang II之外，Ang -（1 - 7）也参与了VLM中肾素 - 血管紧张素系统心血管作用的介导。
