Golstein M A, Manto M, Noel J C, Appelboom T
Division of Rheumatology, Erasmus University Hospital, University of Brussels.
Clin Rheumatol. 1994 Mar;13(1):119-22. doi: 10.1007/BF02229880.
This case reports documents the progressive development of chronic interstitial cystitis during the overlapping process from rheumatoid arthritis to lupus. Concomitantly high titer antinuclear antibody with an anti-68 KD RNP pattern and other biological markers of lupus were observed in the blood. The symptoms dramatically improved under methotrexate therapy. The pathogenic mechanism is discussed.