Gupta R K, Naran S, McHutchison A G, Lallu S, Fauck R J
Department of Laboratory Services, Wellington Hospital and School of Medicine, New Zealand.
Diagn Cytopathol. 1994;10(2):126-9. doi: 10.1002/dc.2840100206.
During a ten year period, since we introduced needle aspiration cytology at our institution, we have diagnosed five cases of umbilical metastasis (Sister Mary Joseph's nodule). In none of the cases was any false negative or false positive diagnosis rendered and the primary carcinoma was found below the diaphragm. In all the five cases, cell blocks of the aspirate were subsequently prepared, and highlighted the histologic features of the tumour which corresponded with the cytologic diagnosis. Immunohistochemical staining on the aspirate material in all the cases was considered quite useful in substantiating the cytohistologic diagnosis. Based on our findings, we suggest that fine-needle aspiration cytology as an initial diagnostic procedure in cases suspected of umbilical metastasis should be considered, since it is not only a simple, fast, accurate, and inexpensive diagnostic procedure, but can also save the patient from an invasive surgical procedure, the benefit of which is questionable.
在我们机构引入针吸细胞学检查后的十年间，我们诊断出了5例脐部转移瘤（玛丽·约瑟夫修女结节）。所有病例均未出现假阴性或假阳性诊断，且原发性癌均位于膈肌以下。在这5例病例中，随后均制备了针吸物的细胞块，突出显示了与细胞学诊断相符的肿瘤组织学特征。所有病例中针吸物材料的免疫组织化学染色在证实细胞组织学诊断方面被认为非常有用。基于我们的研究结果，我们建议应考虑将细针穿刺细胞学检查作为疑似脐部转移病例的初始诊断方法，因为它不仅是一种简单、快速、准确且廉价的诊断方法，还能使患者避免接受侵入性手术，而这种手术的益处值得怀疑。
