Githui W A, Kwamanga D, Chakaya J M, Karimi F G, Waiyaki P G
Respiratory Diseases Research Unit, Kenya Medical Research Institute, Nairobi.
East Afr Med J. 1993 Oct;70(10):609-12.
Our experience at the Respiratory Diseases Research Unit (RDRU), over the last 10 years (1981-1990) on the initial drug resistance pattern, focusing on three drugs viz: isoniazid (H), streptomycin (S) and rifampicin (R) is presented. Records on all isolates of M. tuberculosis from one specimen of every newly diagnosed patient recruited countrywide between 1981-1990 were reviewed. We analyzed records of 6,514 isolates and found that total resistance to the three drugs had increased from 8.9% to 14.4%. Resistance to H alone increased from 6.8% to 10.2% while that of S alone from 0.8% to 1.8%. Resistance to R was between 0.1% and 0.3%. Generally, the increase in the resistance trend to both H and S was statistically significant (p = < 0.05 and 0.03, respectively). Although in our analysis we did not address the possible impact of HIV infection, we hope that these findings form a basis for evaluation of this and other possible factors on the emergence of anti-TB drug resistance in future studies.
本文介绍了呼吸疾病研究室（RDRU）在过去10年（1981 - 1990年）对初始耐药模式的研究经验，重点关注三种药物，即异烟肼（H）、链霉素（S）和利福平（R）。回顾了1981 - 1990年间全国范围内新诊断患者每份标本中所有结核分枝杆菌分离株的记录。我们分析了6514株分离株的记录，发现对这三种药物的总耐药率从8.9%上升到了14.4%。单独对H的耐药率从6.8%上升到10.2%，单独对S的耐药率从0.8%上升到1.8%。对R的耐药率在0.1%至0.3%之间。总体而言，对H和S的耐药趋势增加具有统计学意义（p分别为<0.05和0.03）。虽然在我们的分析中没有涉及HIV感染的可能影响，但我们希望这些发现能为未来研究评估这一因素及其他可能因素对耐多药结核病出现的影响奠定基础。
