Lehký F, Dobŝinská E
Vet Med (Praha). 1975 Dec;20(12):715-21.
The antiemetic effect of Pyrimetin (V.V.M.I.) in dogs whose whole body had been irradiated with gamma rays with the dose of 500 R, administred per os, intramuscularly, and subcutaneously, immediately before the exposure and after it in the course of the initial symptoms of the radiation sickness was studied. Decreased emesis occurred after per os administration of Pyrimetin immediately before the whole body irradiation of the dogs. After an intramuscular application before the whole body irradiation two dogs vomitted, and in the case of an i.m. administration after the whole body irradiation one dog vomitted. Subcutaneous application of Pyrimetin to dogs before the whole body irradiation and also after it produced only a 30 p.c. therapeutic effect.
研究了在全身接受500伦琴γ射线照射的犬中，在照射前和照射后，于放射病初始症状期间经口、肌肉注射和皮下注射嘧胺（V.V.M.I.）的止吐作用。在犬全身照射前立即经口给予嘧胺后，呕吐次数减少。在全身照射前肌肉注射后，有两只犬呕吐，而在全身照射后肌肉注射时，有一只犬呕吐。在犬全身照射前和照射后皮下注射嘧胺仅产生30%的治疗效果。
