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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Iossa S, Barletta A, Liverini G

Dipartimento di Fisiologia Generale ed Ambientale, Università di Napoli, Italy.

Int J Biochem. 1994 Mar;26(3):425-31. doi: 10.1016/0020-711x(94)90063-9.

We have studied fatty acid oxidation and ketone bodies production in liver mitochondria from rats exposed to cold for 10 days and in rats adapted to cold for 40 days. We have examined State 3 respiration and ketone bodies production with palmitoylcarnitine as substrate in isolated mitochondria, together with mitochondrial protein mass and hepatocyte oxygen consumption. 2. Mitochondrial protein mass increases both in cold exposed and in cold adapted rats. 3. State 3 respiration and hepatocyte respiration increase only in cold exposed rats. 4. Ketone bodies production increases in cold adapted rats. 5. Taken together, our results suggest that the increased hepatic mitochondrial protein mass and the increased fatty acid oxidation subserve two different roles: an increase in ATP production in cold exposed rats and an increase in ketone bodies production in cold adapted rats.

我们研究了暴露于寒冷环境10天的大鼠以及适应寒冷环境40天的大鼠肝脏线粒体中的脂肪酸氧化和酮体生成情况。我们在分离的线粒体中以棕榈酰肉碱为底物检测了状态3呼吸和酮体生成，同时检测了线粒体蛋白质量和肝细胞耗氧量。2. 暴露于寒冷环境和适应寒冷环境的大鼠线粒体蛋白质量均增加。3. 仅暴露于寒冷环境的大鼠状态3呼吸和肝细胞呼吸增加。4. 适应寒冷环境的大鼠酮体生成增加。5. 综合来看，我们的结果表明，肝脏线粒体蛋白质量增加和脂肪酸氧化增加发挥了两种不同的作用：在暴露于寒冷环境的大鼠中增加ATP生成，在适应寒冷环境的大鼠中增加酮体生成。

Iossa S, Barletta A, Liverini G

Dipartimento di Fisiologia Generale ed Ambientale, Università di Napoli, Italy.

Int J Biochem. 1994 Mar;26(3):425-31. doi: 10.1016/0020-711x(94)90063-9.

We have studied fatty acid oxidation and ketone bodies production in liver mitochondria from rats exposed to cold for 10 days and in rats adapted to cold for 40 days. We have examined State 3 respiration and ketone bodies production with palmitoylcarnitine as substrate in isolated mitochondria, together with mitochondrial protein mass and hepatocyte oxygen consumption. 2. Mitochondrial protein mass increases both in cold exposed and in cold adapted rats. 3. State 3 respiration and hepatocyte respiration increase only in cold exposed rats. 4. Ketone bodies production increases in cold adapted rats. 5. Taken together, our results suggest that the increased hepatic mitochondrial protein mass and the increased fatty acid oxidation subserve two different roles: an increase in ATP production in cold exposed rats and an increase in ketone bodies production in cold adapted rats.

我们研究了暴露于寒冷环境10天的大鼠以及适应寒冷环境40天的大鼠肝脏线粒体中的脂肪酸氧化和酮体生成情况。我们在分离的线粒体中以棕榈酰肉碱为底物检测了状态3呼吸和酮体生成，同时检测了线粒体蛋白质量和肝细胞耗氧量。2. 暴露于寒冷环境和适应寒冷环境的大鼠线粒体蛋白质量均增加。3. 仅暴露于寒冷环境的大鼠状态3呼吸和肝细胞呼吸增加。4. 适应寒冷环境的大鼠酮体生成增加。5. 综合来看，我们的结果表明，肝脏线粒体蛋白质量增加和脂肪酸氧化增加发挥了两种不同的作用：在暴露于寒冷环境的大鼠中增加ATP生成，在适应寒冷环境的大鼠中增加酮体生成。