丙二酰辅酶A在肝脏脂肪酸氧化和酮体生成调节中的可能作用。
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
作者信息
McGarry J D, Mannaerts G P, Foster D W
出版信息
J Clin Invest. 1977 Jul;60(1):265-70. doi: 10.1172/JCI108764.
Abstract
Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
摘要
在取自喂食和禁食大鼠的肝脏匀浆和线粒体组分中，对油酸和辛酸氧化生成酮体进行了研究。丙二酸单酰辅酶A抑制前者生成酮体，但不抑制后者底物生成酮体。抑制位点似乎是肉碱脂酰转移酶I反应。该效应具有特异性且易于逆转。抑制浓度在其他研究者从喂食大鼠肝脏中获得的值范围内。有人提出，丙二酸单酰辅酶A既是脂肪酸合成的前体，又是脂肪酸氧化的抑制剂。因此，它可能是碳水化合物诱导的脂肪酸氧化节约现象中的一个重要因素。
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