对硕大利什曼原虫免疫的小鼠再次感染后，产生γ干扰素的CD8 + T细胞的扩增
Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major.
作者信息
Müller I, Kropf P, Louis J A, Milon G
机构信息
World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland.
出版信息
Infect Immun. 1994 Jun;62(6):2575-81. doi: 10.1128/iai.62.6.2575-2581.1994.
Abstract
Reinfection of immune mice with Leishmania major elicits a secondary gamma interferon (IFN-gamma) response to which specific CD8+ T cells are essential. We have shown previously that specific CD8+ T cells from reinfected immune mice release substantially higher levels of IFN-gamma, a cytokine essential for the efficient activation of parasitized macrophages to kill intracellular L. major. By using an ELISPOT assay, which allows the detection of IFN-gamma production by individual cells, it is shown here that this elevated IFN-gamma response is the result of an increase of up to 50-fold in the frequency of parasite-specific CD8+ T lymphocytes in the spleens and draining lymph nodes of both immune reinfected CBA and BALB/c mice. This observation is additional evidence of the role that CD8+ T cells play in immunity to reinfection with L. major.
摘要
用硕大利什曼原虫再次感染免疫小鼠会引发二次γ干扰素（IFN-γ）应答，而特异性CD8⁺ T细胞对此应答至关重要。我们之前已经表明，来自再次感染的免疫小鼠的特异性CD8⁺ T细胞释放的IFN-γ水平显著更高，IFN-γ是有效激活被寄生巨噬细胞以杀死细胞内硕大利什曼原虫所必需的一种细胞因子。通过使用一种能检测单个细胞产生IFN-γ的ELISPOT分析方法，本文表明这种升高的IFN-γ应答是免疫再次感染的CBA和BALB/c小鼠脾脏和引流淋巴结中寄生虫特异性CD8⁺ T淋巴细胞频率增加高达50倍的结果。这一观察结果进一步证明了CD8⁺ T细胞在抵抗硕大利什曼原虫再次感染的免疫中所起的作用。
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