Müller I
World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland.
Eur J Immunol. 1992 Dec;22(12):3063-9. doi: 10.1002/eji.1830221206.
The contributions of different T cell subpopulations to the maintenance of immunity during secondary Leishmania major infections were analyzed in healed, resistant animals by depletion of T cell subsets in vivo. The strong delayed-type hypersensitivity mounted in immune genetically resistant mice upon challenge with viable promastigotes was mediated by both CD4+ and CD8+ T cells. Each T cell subpopulation alone contributes, although to a different extent, to the resolution of secondary lesions; both subsets, however, are required for an efficient and rapid healing of the secondary lesions and the decrease in the parasite burden in infected tissues. The results indicate that in immune, genetically resistant CBA mice, the activity of both T cell subsets is required for successful resistance to reinfection and an efficient maintenance of immunity.
通过在体内消耗T细胞亚群，分析了不同T细胞亚群对已治愈的抗性动物在第二次硕大利什曼原虫感染期间维持免疫的贡献。在用活前鞭毛体攻击时，免疫遗传抗性小鼠产生的强烈迟发型超敏反应由CD4 +和CD8 + T细胞介导。每个T细胞亚群单独都有贡献，尽管程度不同，有助于继发性病变的消退；然而，两个亚群都是继发性病变有效快速愈合以及感染组织中寄生虫负荷降低所必需的。结果表明，在免疫的、遗传抗性的CBA小鼠中，两个T细胞亚群的活性对于成功抵抗再感染和有效维持免疫是必需的。
