衰老过程中布鲁赫膜、脉络膜毛细血管和脉络膜的形态计量学分析。

Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.

作者信息

Ramrattan R S, van der Schaft T L, Mooy C M, de Bruijn W C, Mulder P G, de Jong P T

机构信息

Department of Ophthalmology, Erasmus University, Rotterdam, The Netherlands.

出版信息

Invest Ophthalmol Vis Sci. 1994 May;35(6):2857-64.

PMID:8188481

Abstract

PURPOSE

To quantify changes in choriocapillary density and in thickness of Bruch's membrane, the choriocapillaris, and the choroid in 95 unpaired, histologically normal human maculae aged 6 to 100 years and in 25 maculae with advanced age-related macular degeneration.

METHODS

Light microscopic, computer-aided, morphometric quantitative analysis.

RESULTS

In ten decades, Bruch's membrane thickness increased by 135%, from 2.0 to 4.7 microns; the choriocapillary density decreased by 45%; the diameter of the choriocapillaris decreased by 34%, from 9.8 to 6.5 microns; and the choroidal thickness decreased by 57%, from 193.5 to 84 microns in normal maculae. In maculae with basal laminar deposit, geographic atrophy, or disciform scarring, the density of the choriocapillaris was 63%, 54%, and 43% of normal and the choriocapillary diameter was 81%, 73%, and 75% of normal, respectively. Choroidal thickness remained unchanged.

CONCLUSIONS

Thickness of Bruch's membrane was only related to age (rs = 0.63) and not to age-related atrophy of the choriocapillaris. Age was also the strongest factor related to choriocapillary density (rs = -0.58). In advanced stages of age-related macular degeneration, the decrease in choriocapillary density and diameter was significantly larger than in normal maculae, but the thickness of the choroid and Bruch's membrane was the same. The latter was significantly thinner (81% of normal) in disciform scarring.

摘要

目的

量化95例年龄在6至100岁之间、组织学检查正常的未配对人黄斑以及25例患有晚期年龄相关性黄斑变性的黄斑中脉络膜毛细血管密度、布鲁赫膜厚度、脉络膜毛细血管层和脉络膜的变化。

方法

光学显微镜下计算机辅助形态计量学定量分析。

结果

在十个十年中，布鲁赫膜厚度增加了135%，从2.0微米增至4.7微米；脉络膜毛细血管密度降低了45%；脉络膜毛细血管直径降低了34%，从9.8微米降至6.5微米；正常黄斑中脉络膜厚度降低了57%，从193.5微米降至84微米。在有基底膜沉积物、地图状萎缩或盘状瘢痕形成的黄斑中，脉络膜毛细血管密度分别为正常的63%、54%和43%，脉络膜毛细血管直径分别为正常的81%、73%和75%。脉络膜厚度保持不变。

结论

布鲁赫膜厚度仅与年龄相关（rs = 0.63），与脉络膜毛细血管的年龄相关性萎缩无关。年龄也是与脉络膜毛细血管密度相关的最强因素（rs = -0.58）。在年龄相关性黄斑变性的晚期，脉络膜毛细血管密度和直径的降低显著大于正常黄斑，但脉络膜和布鲁赫膜的厚度相同。在盘状瘢痕形成中，后者明显更薄（为正常的81%）。