Wannamethee G, Shaper A G, Whincup P H
Department of Public Health, Royal Free Hospital School of Medicine, London.
J Epidemiol Community Health. 1994 Apr;48(2):112-8. doi: 10.1136/jech.48.2.112.
To assess the relationship between haematocrit and risk of major ischaemic heart disease events.
Prospective study of a cohort of men followed up for 9.5 years.
General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study).
Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general practice in each of 24 towns, were studied.
Fatal and nonfatal ischaemic heart disease events.
Risk of major ischaemic heart disease events was significantly increased at haematocrit levels of > or = 46.0%. Men with raised haematocrit (> or = 46.0%) showed a 30% increase in relative risk (RR) of major ischaemic heart disease events (RR = 1.32; 95% confidence intervals (CI) 1.10,1.57, p < 0.01) compared with those with values below 46.0%, even after adjustment for age, social class, smoking, body mass index, physical activity, blood cholesterol, lung function (FEV1), and pre-existing evidence of ischaemic heart disease. Further adjustment for systolic blood pressure reduced the risk slightly (RR = 1.27; 95% CI 1.06,1.51, p = 0.02) but it remained significant. The relationship was seen in men with and without pre-existing evidence of ischaemic heart disease. The study suggests that an increased haematocrit level plays a part in the development of major ischaemic heart disease events.
评估血细胞比容与主要缺血性心脏病事件风险之间的关系。
对一组男性进行为期9.5年的前瞻性研究。
英格兰、威尔士和苏格兰24个城镇的普通诊所（英国地区心脏研究）。
共研究了7735名在筛查时年龄为40 - 59岁的男性，他们是从24个城镇中每个城镇的一家普通诊所随机选取的。
致命和非致命性缺血性心脏病事件。
血细胞比容水平≥46.0%时，主要缺血性心脏病事件的风险显著增加。血细胞比容升高（≥46.0%）的男性与血细胞比容低于46.0%的男性相比，主要缺血性心脏病事件的相对风险增加了30%（相对风险 = 1.32；95%置信区间为1.10, 1.57，p < 0.01），即使在调整了年龄、社会阶层、吸烟、体重指数、身体活动、血胆固醇、肺功能（第一秒用力呼气量）以及既往缺血性心脏病证据之后。进一步调整收缩压后风险略有降低（相对风险 = 1.27；95%置信区间为1.06, 1.51，p = 0.02），但仍具有显著性。在有和没有既往缺血性心脏病证据的男性中均观察到这种关系。该研究表明血细胞比容水平升高在主要缺血性心脏病事件的发生中起作用。
