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Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.

作者信息

Friedrich T D, Laffin J, Lehman J M

机构信息

Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.

出版信息

J Virol. 1994 Jun;68(6):4028-30. doi: 10.1128/JVI.68.6.4028-4030.1994.

Abstract

Previous experiments with the simian virus 40 mutant tsA357R-K (tsA30) demonstrated a T-antigen function that is required for production of cells with a greater-than-G2-phase DNA content. In this study, temperature shift experiments indicated that the temperature-sensitive function of tsA357R-K, which is necessary for entry into the greater-than-G2 phase, is not required in G1 or S but must be supplied in the G2 phase.

摘要

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