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猿猴病毒40诱导四倍体DNA含量取决于细胞周期G2期的T抗原功能。

Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.

作者信息

Friedrich T D, Laffin J, Lehman J M

机构信息

Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.

出版信息

J Virol. 1994 Jun;68(6):4028-30. doi: 10.1128/JVI.68.6.4028-4030.1994.

DOI:10.1128/JVI.68.6.4028-4030.1994
PMID:8189537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC236910/
Abstract

Previous experiments with the simian virus 40 mutant tsA357R-K (tsA30) demonstrated a T-antigen function that is required for production of cells with a greater-than-G2-phase DNA content. In this study, temperature shift experiments indicated that the temperature-sensitive function of tsA357R-K, which is necessary for entry into the greater-than-G2 phase, is not required in G1 or S but must be supplied in the G2 phase.

摘要

先前对猿猴病毒40突变体tsA357R-K（tsA30）进行的实验表明，T抗原功能对于产生DNA含量大于G2期的细胞是必需的。在本研究中，温度转换实验表明，tsA357R-K的温度敏感功能是进入大于G2期所必需的，在G1期或S期不需要，但在G2期必须具备。

相似文献

1
Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.猿猴病毒40诱导四倍体DNA含量取决于细胞周期G2期的T抗原功能。
J Virol. 1994 Jun;68(6):4028-30. doi: 10.1128/JVI.68.6.4028-4030.1994.
2
Simian virus 40 large T-antigen function is required for induction of tetraploid DNA content during lytic infection.在裂解感染期间诱导四倍体DNA含量需要猿猴病毒40大T抗原发挥功能。
J Virol. 1992 Jul;66(7):4576-9. doi: 10.1128/JVI.66.7.4576-4579.1992.
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Activities of SV40 T antigen necessary for the induction of tetraploid DNA content in permissive CV-1 cells.在允许性CV-1细胞中诱导四倍体DNA含量所必需的SV40 T抗原活性。
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Correlation of DNA content, p53, T antigen, and V antigen in simian virus 40-infected human diploid cells.猴病毒40感染的人二倍体细胞中DNA含量、p53、T抗原和V抗原的相关性
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Hypophosphorylated retinoblastoma gene product accumulates in SV40-infected CV-1 cells acquiring a tetraploid DNA content.低磷酸化视网膜母细胞瘤基因产物在感染SV40的CV-1细胞中积累，这些细胞获得了四倍体DNA含量。
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Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.由温度敏感型猿猴病毒40大T抗原基因建立的细胞系在非允许温度下生长受限。
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Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts.猿猴病毒40小T抗原的过表达会阻断人成纤维细胞中的中心体功能和有丝分裂进程。
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本文引用的文献

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Quantitation of simian virus 40 T-antigen correlated with the cell cycle of permissive and non-permissive cells.猿猴病毒40 T抗原的定量与允许细胞和非允许细胞的细胞周期相关。
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Analysis of simian virus 40 infection of CV-1 cells by quantitative two-color fluorescence with flow cytometry.运用流式细胞术的定量双色荧光分析法对CV-1细胞的猿猴病毒40感染情况进行分析。
Cytometry. 1988 Jan;9(1):52-9. doi: 10.1002/cyto.990090109.
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Correlation of DNA content, p53, T antigen, and V antigen in simian virus 40-infected human diploid cells.猴病毒40感染的人二倍体细胞中DNA含量、p53、T抗原和V抗原的相关性
Cytometry. 1989 Mar;10(2):205-13. doi: 10.1002/cyto.990100212.
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The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1.
Cell. 1992 Nov 13;71(4):599-611. doi: 10.1016/0092-8674(92)90594-3.
10
Simian virus 40 large T-antigen function is required for induction of tetraploid DNA content during lytic infection.在裂解感染期间诱导四倍体DNA含量需要猿猴病毒40大T抗原发挥功能。
J Virol. 1992 Jul;66(7):4576-9. doi: 10.1128/JVI.66.7.4576-4579.1992.