猿猴病毒40诱导四倍体DNA含量取决于细胞周期G2期的T抗原功能。
Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.
作者信息
Friedrich T D, Laffin J, Lehman J M
机构信息
Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.
出版信息
J Virol. 1994 Jun;68(6):4028-30. doi: 10.1128/JVI.68.6.4028-4030.1994.
Abstract
Previous experiments with the simian virus 40 mutant tsA357R-K (tsA30) demonstrated a T-antigen function that is required for production of cells with a greater-than-G2-phase DNA content. In this study, temperature shift experiments indicated that the temperature-sensitive function of tsA357R-K, which is necessary for entry into the greater-than-G2 phase, is not required in G1 or S but must be supplied in the G2 phase.
摘要
先前对猿猴病毒40突变体tsA357R-K（tsA30）进行的实验表明，T抗原功能对于产生DNA含量大于G2期的细胞是必需的。在本研究中，温度转换实验表明，tsA357R-K的温度敏感功能是进入大于G2期所必需的，在G1期或S期不需要，但在G2期必须具备。
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