Nakaki T
Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Keio J Med. 1994 Mar;43(1):15-26. doi: 10.2302/kjm.43.15.
Nitric oxide, or NO., is a gas under atmospheric conditions. It is noxious because of its free-radical structure. It is biosynthesized from the amino acid L-arginine. The responsible enzymes are widely distributed in the human body. It has been shown that this simple molecule, NO., plays important roles in mammalian physiology. It is one of the factors regulating vascular tone and blood pressure, inhibition of platelet aggregation, neurotransmission in the peripheral and central nervous systems and macrophage function. Evidence for the pathophysiological significance of NO. is now accumulating.
一氧化氮（NO.）在大气条件下是一种气体。由于其自由基结构，它具有毒性。它由氨基酸L-精氨酸生物合成。相关酶在人体中广泛分布。研究表明，这种简单分子NO.在哺乳动物生理学中发挥着重要作用。它是调节血管张力和血压、抑制血小板聚集、外周和中枢神经系统神经传递以及巨噬细胞功能的因素之一。现在，关于NO.病理生理学意义的证据正在不断积累。
