Garini G, Savazzi G, Borghetti A
Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università, Parma.
Recenti Prog Med. 1997 Feb;88(2):90-9.
In this review we describe what is known about nitric oxide (NO), focusing on its clinical significance. It is now well appreciated that NO is a pivotal endogenous messenger molecule in a variety of physiological and pathophysiological processes. In the cardiovascular system NO participates in the paracrine regulation of vascular tone, body fluid homeostasis and platelet aggregation and adhesion. In the nervous system NO is a neurotransmitter that underpins several functions, including the formation of memory. In addition, NO is produced in large quantities during host defense and immunologic reactions. Perturbation in NO bioactivity has been shown to represent an important pathophysiologic mechanism underlying a number of disease states, such as atherosclerosis, hypertension, diabetes mellitus, and septic shock.
在本综述中，我们描述了关于一氧化氮（NO）的已知信息，重点关注其临床意义。现在人们已经充分认识到，NO是多种生理和病理生理过程中的关键内源性信使分子。在心血管系统中，NO参与血管张力、体液稳态以及血小板聚集和黏附的旁分泌调节。在神经系统中，NO是一种神经递质，支撑着包括记忆形成在内的多种功能。此外，在宿主防御和免疫反应过程中会大量产生NO。NO生物活性的紊乱已被证明是多种疾病状态（如动脉粥样硬化、高血压、糖尿病和脓毒性休克）背后的重要病理生理机制。
