Müller K, Ebner B, Hömberg V
Department of Pediatrics, Heinrich-Heine-Universität Düsseldorf, FRG.
Neurosci Lett. 1994 Jan 17;166(1):9-12. doi: 10.1016/0304-3940(94)90828-1.
The maturation of the fastest afferent and efferent central and peripheral pathways was analysed using the recording of somatosensory evoked potentials of the median nerve stimulation for afferent conduction and magnetoelectrical stimulation of motor cortex to the thenar muscles for efferent conduction. Both afferent and efferent central pathways showed a prolonged maturational pattern with adult values being reached by the age of 5 to 7 years for the afferent and by the age of around 10 years for the efferent pathway. In contrast, the maturation for peripheral afferent and efferent pathways showed a similar trend with a fairly constant conduction velocity reached around the age of 3 years. There was no evidence for a constancy of central conduction delays in both afferent and efferent pathway which has been supposed as a possible mechanism for a temporal stability in feedback loops involved in motor learning processes during development. It is concluded that the prolonged maturational central conduction time precludes the usage of a fixed temporal timing pattern during development in the human sensory motor system.
通过记录正中神经刺激的体感诱发电位以分析传入传导，以及对运动皮层至鱼际肌进行磁电刺激以分析传出传导，来研究最快的传入和传出中枢及外周通路的成熟情况。传入和传出中枢通路均呈现出延长的成熟模式，传入通路在5至7岁时达到成人值，传出通路在约10岁时达到成人值。相比之下，外周传入和传出通路的成熟呈现出相似趋势，在3岁左右达到相当稳定的传导速度。没有证据表明传入和传出通路的中枢传导延迟具有稳定性，而这曾被认为是发育过程中运动学习过程中反馈回路时间稳定性的一种可能机制。得出的结论是，中枢传导时间延长的成熟过程排除了人类感觉运动系统在发育过程中使用固定时间模式的可能性。
