Moustafa H M, Omar W M, Ezzat I, Ziada G A, el-Ghonimy E G
Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Cairo University, Egypt.
Nucl Med Commun. 1994 Mar;15(3):140-3. doi: 10.1097/00006231-199403000-00003.
Twenty-five patients with malignant astrocytoma, either postoperatively (15 cases) or with recurrent tumour versus gliosis (10 cases) were included in this study. 201Tl single photon emission computed tomography (SPECT) was performed with the calculation of early and delayed uptake values and retention index. A high mean value of early and delayed uptake correlated with a low retention index in patients with high-grade astrocytoma in both postoperative residual and recurrent groups, versus a lower mean value of early and delayed uptake with a high retention index in patients with low-grade tumours. All postoperative cases with high-grade astrocytoma had high 201Tl uptake > 1.5, whereas 66.6% of cases with low-grade astrocytoma had low 201Tl uptake < 1.5. There was a correlation between retention index of 201Tl and tumour grade with r = 0.47. Also, recurrent cases showed remarkable differences in early and delayed 201Tl uptake (P < 0.05) and retention index (P < 0.001) compared with postradiation gliosis. There was a higher sensitivity in detection of tumour viability by 201Tl SPECT of 100% versus 80% using computed tomographic scanning and in the differentiation between recurrent tumour and postradiation gliosis.
本研究纳入了25例恶性星形细胞瘤患者，其中15例为术后患者，10例为复发肿瘤合并胶质增生患者。进行了201Tl单光子发射计算机断层扫描（SPECT），并计算了早期和延迟摄取值以及滞留指数。在术后残留组和复发组的高级别星形细胞瘤患者中，早期和延迟摄取的高平均值与低滞留指数相关，而在低级别肿瘤患者中，早期和延迟摄取的平均值较低且滞留指数较高。所有高级别星形细胞瘤术后病例的201Tl摄取均较高，>1.5，而66.6%的低级别星形细胞瘤病例的201Tl摄取较低，<1.5。201Tl的滞留指数与肿瘤分级之间存在相关性，r = 0.47。此外，与放射性胶质增生相比，复发病例在早期和延迟201Tl摄取（P < 0.05）和滞留指数（P < 0.001）方面表现出显著差异。201Tl SPECT检测肿瘤存活能力的敏感性更高，为100%，而计算机断层扫描的敏感性为80%，且在区分复发肿瘤和放射性胶质增生方面也更具优势。
