Igase K, Oka Y, Ohta S, Murakami Y, Kumon Y, Sakaki S
Department of Neurological Surgery, Ehime University School of Medicine.
Neurol Med Chir (Tokyo). 1996 Jul;36(7):434-9. doi: 10.2176/nmc.36.434.
Preoperative thallium-201 (201Tl) single photon emission computed tomography (SPECT) was used to evaluate the histological malignancy in 24 patients with brain tumors. A corrected L/E ratio was calculated based on the ratio of thallium uptake in the tumor on early images versus the tumor in the delayed images (L/E ratio) corrected for thallium uptake in the contralateral cerebral hemisphere. The corrected L/E ratio in benign brain tumors was 0.79 +/- 0.23, significantly different to 1.32 +/- 0.25 in high grade astrocytomas (p < 0.01) and 1.19 +/- 0.05 in metastatic brain tumors (p < 0.01), respectively. The corrected L/E ratio in low grade astrocytomas was 0.64 +/- 0.32, significantly lower than that in high grade astrocytomas (p < 0.01) and metastatic brain tumors (p < 0.05). There was one false positive result among 24 patients using a threshold of 1.0 to separate malignant and benign tumors. 201Tl SPECT using the corrected L/E ratio is effective for determining the malignant viability of tumors.
术前采用铊-201（²⁰¹Tl）单光子发射计算机断层扫描（SPECT）对24例脑肿瘤患者的组织学恶性程度进行评估。根据早期图像上肿瘤的铊摄取量与延迟图像上肿瘤的铊摄取量之比（L/E比值），并对侧脑半球的铊摄取量进行校正，计算校正后的L/E比值。良性脑肿瘤的校正L/E比值为0.79±0.23，与高级别星形细胞瘤的1.32±0.25（p<0.01）和脑转移瘤的1.19±0.05（p<0.01）有显著差异。低级别星形细胞瘤的校正L/E比值为0.64±0.32，显著低于高级别星形细胞瘤（p<0.01）和脑转移瘤（p<0.05）。在24例患者中，以1.0为阈值区分恶性和良性肿瘤时有1例假阳性结果。使用校正后的L/E比值的²⁰¹Tl SPECT对确定肿瘤的恶性生存能力有效。
