[肿瘤和正常组织中格罗斯白血病病毒的型特异性抗原及其免疫扩散法鉴定]
[The type specific antigen of Gross leukemia virus in tumors and normal tissues and its identification by immunodiffusion methods].
作者信息
Lezhneva O M
出版信息
Biull Eksp Biol Med. 1976 Feb;81(2):217-9.
PMID:819062
Abstract
A monospecific antiserum for type-specific antigen of Gross virus (AGLV) was obtained. Tumours of different origin were studied with this monospecific antiserum in the gel-diffusion test. AGLV was revealed in spontaneous kidney tumour of CC57BR mice, and in chemically (carcinogen)- induced tumours of mice. These findings suggest activation of MuLV viral genom in low-leukemic strains of mice.
摘要
获得了一种针对格罗斯病毒（AGLV）型特异性抗原的单特异性抗血清。用这种单特异性抗血清在凝胶扩散试验中研究了不同来源的肿瘤。在CC57BR小鼠的自发性肾肿瘤以及化学（致癌物）诱导的小鼠肿瘤中发现了AGLV。这些发现提示在低白血病小鼠品系中莫洛尼白血病病毒（MuLV）基因组被激活。
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