Duś D, Harlozińska A, Skriabin A, Richter R
Arch Immunol Ther Exp (Warsz). 1976;24(5):727-40.
The continuous AKR 87 cell line was derived from the thymus and spleen of AKR mice with spontaneous leukemia. Previous studies showed that the line has retained the original morphologic features of leukemic cells, reacts positively in the XC test, and produces virus particles of type C morphology. The present paper presents an immunologic characterization of cells of the AKR 87 line and of the virus produced by them, in comparison with the cells of spontaneous leukemia of AKR mice, TGV line productively infected with Gross virus, and normal mouse tissues. Results of the hemagglutination test, immunoprecipitation in agar gel, cytotoxic test and immunofluorescence indicate that the AKR 87 line produces virus antigen of the Gross type.
连续的AKR 87细胞系源自患有自发性白血病的AKR小鼠的胸腺和脾脏。先前的研究表明，该细胞系保留了白血病细胞的原始形态特征，在XC试验中呈阳性反应，并产生C型形态的病毒颗粒。本文对AKR 87细胞系的细胞及其产生的病毒进行了免疫学特征分析，并与AKR小鼠自发性白血病细胞、被格罗斯病毒有效感染的TGV细胞系以及正常小鼠组织进行了比较。血凝试验、琼脂凝胶免疫沉淀、细胞毒性试验和免疫荧光试验的结果表明，AKR 87细胞系产生格罗斯型病毒抗原。
