Nylén P, Hagman M
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
Pharmacol Toxicol. 1994 Feb;74(2):124-9. doi: 10.1111/j.1600-0773.1994.tb01086.x.
Rats were exposed to xylene, to n-hexane, or to xylene together with n-hexane, each solvent 1000 p.p.m. (1000 + 1000 p.p.m. in mixed exposure), 18 hr/day, 7 days/week during 61 days. Neurophysiological recordings were made 2 days, 4 months, and 10 months after the end of exposure. Exposure to n-hexane alone, or xylene alone, caused a slight loss of auditory sensitivity as recorded by auditory brainstem response 2 days after the exposure. Exposure to n-hexane together with xylene caused persistent loss of auditory sensitivity (7-17 dB; P < 0.05) which was non-additively enhanced (P < 0.01). The latencies of the flash evoked potentials in the group exposed to n-hexane alone were prolonged (re C group) 2 days after exposure, while smaller prolongations were found in the group exposed to xylene together with n-hexane. Exposure to n-hexane alone caused a marked decrease in nerve conduction velocity, while simultaneous exposure to xylene inhibited n-hexane-induced velocity reduction in peripheral nerve (P < 0.01).
将大鼠暴露于二甲苯、正己烷或二甲苯与正己烷的混合物中，每种溶剂浓度为1000 ppm（混合暴露时为1000 + 1000 ppm），每天暴露18小时，每周暴露7天，持续61天。在暴露结束后2天、4个月和10个月进行神经生理学记录。暴露后2天，单独暴露于正己烷或二甲苯时，听觉脑干反应记录显示听觉敏感性略有下降。暴露于正己烷和二甲苯的混合物导致听觉敏感性持续下降（7 - 17 dB；P < 0.05），且这种下降是非相加性增强的（P < 0.01）。单独暴露于正己烷的组在暴露后2天闪光诱发电位潜伏期延长（相对于对照组），而同时暴露于二甲苯和正己烷的组潜伏期延长较小。单独暴露于正己烷导致神经传导速度显著降低，而同时暴露于二甲苯可抑制正己烷诱导的外周神经传导速度降低（P < 0.01）。
