氯丙嗪对猴子的低温作用。
Hypothermic action of chlorpromazine in monkeys.
作者信息
Chai C Y, Fann Y D, Lin M T
出版信息
Br J Pharmacol. 1976 May;57(1):43-9. doi: 10.1111/j.1476-5381.1976.tb07654.x.
Abstract
1 In the conscious monkey (Macaca cyclopis) intravenous administration of chlorpromazine 0.1-8.0 mg/kg produced a fall of rectal temperature of 0.3 to 3.5 degrees C after a latency of 3.5 to 10.8 minutes. The course of hypothermia lasted from 125 to 600 min or more. 2 Direct injection of chlorpromazine 100-800 mug into the lateral or fourth cerebral ventricle produced a similar fall of 0.3 to 2.0 degrees C but with shorter latency (2 to 3.5 min) and with a duration of 94 to 375 minutes. 3 Two distinct structures in the brain stem, namely, the preoptic anterior hypothalamus (POAH) and medulla oblongata, responded to direct injection of chlorpromazine 200 mug. The sensitivity was slightly higher in the POAH than in the medulla. Structures in between were not sensitive. 4 The results suggest that chlorpromazine works principally through the central nervous system, i.e. the POAH and medulla oblongata, to mediate its hypothermic effect.
摘要
- 在清醒的猕猴（食蟹猴）中，静脉注射0.1 - 8.0毫克/千克的氯丙嗪，在3.5至10.8分钟的潜伏期后，直肠温度下降0.3至3.5摄氏度。体温过低的过程持续125至600分钟或更长时间。2. 直接向侧脑室或第四脑室注射100 - 800微克氯丙嗪会产生类似的0.3至2.0摄氏度的下降，但潜伏期较短（2至3.5分钟），持续时间为94至375分钟。3. 脑干中有两个不同的结构，即视前区下丘脑前部（POAH）和延髓，对直接注射200微克氯丙嗪有反应。POAH的敏感性略高于延髓。两者之间的结构不敏感。4. 结果表明，氯丙嗪主要通过中枢神经系统，即POAH和延髓，来介导其降温作用。
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