Larue-Achagiotis C, Goubern M, Laury M C, Louis-Sylvestre J
Neurobiologie de la Nutrition, C.N.R.S., E.P.H.E., France.
Physiol Behav. 1994 Mar;55(3):483-7. doi: 10.1016/0031-9384(94)90104-x.
Food intake and body weight gain were examined in two groups of male rats (7 weeks): an inbred strain, Dark Agouti (DA, n = 12) and a noninbred strain, Wistar (n = 13). The animals were allowed to select their diet from separate sources of the three macronutrients protein, fat, and carbohydrate. After 10 days of adaptation to the diets, body weights and food intakes were measured for 3 weeks. During this period, meal patterns were recorded for at least 5 days in each rat. Then, rats were switched to a chow diet (UAR, A.O4) for 10 days. The total caloric intake of DA rats was 60% that of Wistar rats, while their body weight gain was 25% that of Wistar rats (1.3 g/day in DA vs. 5.3 g in Wistar). However, when energy intake was related to total body weight, there was no difference in energy ingestion. It was observed that DA rats ingested mainly proteins (45%) and fats (41%), while Wistar rats ingested an identical proportion of proteins and carbohydrates (40%). The percent of total white adipose tissue to total body weight was identical in both strains (6% on average). Brown adipose tissue thermogenic activity of DA rats was threefold higher than in Wistar rats. This could be one of the elements responsible for the lower body weight gain of this group of rats. Self-selected food intake of the inbred DA strain of rats, in contrast to what was expected, was greatly variable.
对两组雄性大鼠（7周龄）的食物摄入量和体重增加情况进行了研究：一个近交系，黑褐家鼠（DA，n = 12）和一个非近交系，Wistar大鼠（n = 13）。允许动物从蛋白质、脂肪和碳水化合物这三种宏量营养素的不同来源中选择它们的食物。在适应饮食10天后，测量体重和食物摄入量，持续3周。在此期间，记录每只大鼠至少5天的进食模式。然后，将大鼠换成普通饲料（UAR，A.O4），持续10天。DA大鼠的总热量摄入是Wistar大鼠的60%，而它们的体重增加是Wistar大鼠的25%（DA大鼠为1.3克/天，Wistar大鼠为5.3克/天）。然而，当能量摄入与总体重相关时，能量摄取没有差异。观察到DA大鼠主要摄入蛋白质（45%）和脂肪（41%），而Wistar大鼠摄入的蛋白质和碳水化合物比例相同（40%）。两个品系中白色脂肪组织占总体重的百分比相同（平均为6%）。DA大鼠的棕色脂肪组织产热活性比Wistar大鼠高两倍。这可能是导致这组大鼠体重增加较低的因素之一。与预期相反，近交系DA大鼠的自主食物摄入量差异很大。
