Puzyński S, Koszewska I, Kalinowski A, Bogdanowicz E, Swiecicki L
II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii w Warszawie.
Psychiatr Pol. 1994 Jan-Feb;28(1):5-15.
Among 67 patients admitted for the first time to the hospital drug resistance was evaluated in the further course of disease for at least 3 consecutive depressive phases. It was established that drug resistance occurs (usually as a single episode) in 28% of patients with endogenous depression and it concerns 10% of all depressive phases. The drug resistance is more frequent after the 45th year of life. The incidence of therapeutic failures is 3% during the first depressive phase and goes up in the consecutive phases. The occurrence of drug resistance in the past has no prognostic value for the next phase. There is a certain subgroup of patients, characterized by repetitive drug resistance during several phases. This phenomenon needs further evaluation.
在首次入院的67例患者中，在疾病的后续过程中，对至少连续3个抑郁期进行了耐药性评估。结果发现，内源性抑郁症患者中有28%出现耐药性（通常为单次发作），占所有抑郁期的10%。45岁以后耐药性更为常见。在第一个抑郁期治疗失败的发生率为3%，在后续阶段会上升。过去出现耐药性对下一阶段没有预后价值。有一个特定的患者亚组，其特征是在几个阶段反复出现耐药性。这种现象需要进一步评估。
