Puzyński S, Koszewska I, Kalinowski A, Bogdanowicz E, Swiecicki L
II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii, Warszawie.
Psychiatr Pol. 1993 Nov-Dec;27(6):673-82.
The efficacy of antidepressive treatment (mainly pharmacotherapy) was evaluated among 284 patients, admitted for the first time to the hospital with the diagnosis of endogenous depression. The first antidepressant therapy was found effective in 58% of the patients. Furthermore treatment with other antidepressants in the patients not responding to the initial therapy was successful in 57% of the cases. Drug resistance (defined as no therapeutical effect after 2 adequate courses of antidepressant treatment) was established in 7% of this sample. It was established that the drug resistance is more frequent after the 45th year of life. No relation between the drug resistance and sex, type of affective disorder, life events or somatic disorders were found.
对284例首次因内源性抑郁症入院的患者进行了抗抑郁治疗（主要是药物治疗）疗效评估。首次抗抑郁治疗在58%的患者中被发现有效。此外，对初始治疗无反应的患者使用其他抗抑郁药治疗，57%的病例取得成功。该样本中有7%的患者出现耐药性（定义为经过两个足够疗程的抗抑郁治疗后无治疗效果）。已确定耐药性在45岁以后更为常见。未发现耐药性与性别、情感障碍类型、生活事件或躯体疾病之间存在关联。
