DeRijk R H, Boelen A, Tilders F J, Berkenbosch F
Research Institute Neurosciences Vrije Universiteit, Faculty of Medicine, Department of Pharmacology, Amsterdam, The Netherlands.
Psychoneuroendocrinology. 1994;19(2):155-63. doi: 10.1016/0306-4530(94)90005-1.
Adrenaline, which is secreted from the adrenal medulla during stress, is considered to be involved in the control of inflammation and immune responses. Therefore, we studied the effects of adrenaline on the plasma levels of one of the major pro-inflammatory cytokines, interleukin-6 (IL-6). Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations. The increase in plasma IL-6 in response to adrenaline given by subcutaneous (SC) route and by IV infusion could be blocked by the beta-adrenergic receptor antagonist l-propranolol but not by d-propranolol. Based on these data we conclude that under physiological conditions circulating adrenaline may be involved in the control of IL-6 production, and thereby may modulate inflammatory responses.
肾上腺素在应激期间由肾上腺髓质分泌，被认为参与炎症和免疫反应的调控。因此，我们研究了肾上腺素对主要促炎细胞因子之一白细胞介素-6（IL-6）血浆水平的影响。在此我们描述，在大鼠中，皮下注射肾上腺素会导致血浆IL-6浓度呈剂量依赖性增加，2小时后达到最大值。此外，静脉输注肾上腺素，其剂量导致循环肾上腺素浓度与应激期间观察到的浓度相似，可提高心率并增加血浆IL-6浓度。皮下给药和静脉输注肾上腺素后血浆IL-6的增加可被β-肾上腺素能受体拮抗剂l-普萘洛尔阻断，但不能被d-普萘洛尔阻断。基于这些数据，我们得出结论，在生理条件下，循环中的肾上腺素可能参与IL-6产生的调控，从而可能调节炎症反应。
