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[左旋咪唑在结直肠癌辅助化疗中的毒性]

[Toxicity of levamisole in adjuvant chemotherapy for colorectal cancer].

作者信息

Navarro-Carola E, de Gramont A, Louvet C, Varette C, Demuynck B, Beerblock K, Soubrane D, Grangé J D, Krulik M

机构信息

Service de médecine interne-oncologie, hôpital Saint-Antoine, Paris, France.

出版信息

Rev Med Interne. 1993;14(9):821-4. doi: 10.1016/s0248-8663(05)81139-7.

DOI:10.1016/s0248-8663(05)81139-7
PMID:8191099
Abstract

We studied the levamisole toxic effects in adjuvant therapy for colorectal cancer. The therapy toxic effects on 127 patients were statistically more important in the levamisole-treated group compared to patients treated with folinic acid and 5-fluorouracil alone. Randomized studies in progress will demonstrate the real therapeutic value of levamisole.

摘要

我们研究了左旋咪唑在结直肠癌辅助治疗中的毒性作用。与单独使用亚叶酸和5-氟尿嘧啶治疗的患者相比,左旋咪唑治疗组中127例患者的治疗毒性作用在统计学上更为显著。正在进行的随机研究将证明左旋咪唑的实际治疗价值。

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1
[Toxicity of levamisole in adjuvant chemotherapy for colorectal cancer].[左旋咪唑在结直肠癌辅助化疗中的毒性]
Rev Med Interne. 1993;14(9):821-4. doi: 10.1016/s0248-8663(05)81139-7.
2
Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases.5-氟尿嘧啶和左旋咪唑辅助治疗切除术后结直肠癌期间出现的致残性脑病:两例报告
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Adjuvant regional chemotherapy and systemic chemotherapy versus systemic chemotherapy alone in patients with stage II-III colorectal cancer: a multicentre randomised controlled phase III trial.II-III期结直肠癌患者辅助区域化疗与全身化疗联合与单纯全身化疗的比较:一项多中心随机对照III期试验
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Large scale trial for adjuvant treatment in high risk resected colorectal cancers. Rationale to test the combination of loco-regional and systemic chemotherapy and to compare l-leucovorin + 5-FU to levamisole + 5-FU.高危切除性结直肠癌辅助治疗的大规模试验。测试局部区域化疗与全身化疗联合应用以及比较亚叶酸钙+5-氟尿嘧啶与左旋咪唑+5-氟尿嘧啶的理论依据。
Ann Oncol. 1993;4 Suppl 2:21-8. doi: 10.1093/annonc/4.suppl_2.s21.
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Retrospective evaluation of toxicity in three different schedules of adjuvant chemotherapy for patients with resected colorectal cancer. TTD Spanish Cooperative Group.
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[Progress of adjuvant chemotherapy in colon cancer].[结肠癌辅助化疗的进展]
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Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group.结直肠癌的辅助化疗:北欧胃肠道肿瘤辅助治疗组对随机试验的联合分析
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Adjuvant therapy for colorectal cancer.结直肠癌的辅助治疗。
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[Cytoreductive surgery as an alternative to palliative operations in oncology (the model of treatment of stage IV colorectal cancer)].[减瘤手术作为肿瘤学中姑息手术的替代方案(IV期结直肠癌的治疗模式)]
Vestn Khir Im I I Grek. 2002;161(6):100-3.
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[Interferon-alpha in adjuvant treatment of colorectal carcinoma].[α干扰素在结直肠癌辅助治疗中的应用]
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