Vallat J M, Bordessoule D, Jauberteau M O, Liozon E, Akani F
Service de neurologie, CHU Dupuytren, Limoges, France.
Rev Med Interne. 1993;14(9):841-50. doi: 10.1016/s0248-8663(05)81142-7.
In our experience, the incidence of an association between peripheral neuropathy and hemopathy is around 7%. The corresponding nerve involvement may reveal or complicate a known hemopathy. The exact cause-effect relationship is not always easy to identify. We discuss here the peripheral nerve complications of acute leukemia, myeloproliferative disorders, monoclonal dysglobulinemia, non-Hodgkin's malignant lymphoma and Hodgkin's disease. The peripheral neuropathy arising in cases of monoclonal dysglobulinemia, non-Hodgkin's malignant lymphoma have most benefited from ultrastructural examination and advances in immunological and immunocytochemical techniques. Accurate determination of the lesional mechanism should help devise appropriate therapeutic strategies.
根据我们的经验，周围神经病变与血液病之间关联的发生率约为7%。相应的神经受累可能会揭示已知的血液病或使其复杂化。确切的因果关系并不总是容易确定。我们在此讨论急性白血病、骨髓增殖性疾病、单克隆丙种球蛋白血症、非霍奇金恶性淋巴瘤和霍奇金病的周围神经并发症。单克隆丙种球蛋白血症、非霍奇金恶性淋巴瘤病例中出现的周围神经病变从超微结构检查以及免疫和免疫细胞化学技术的进展中获益最多。准确确定病变机制应有助于制定适当的治疗策略。
