Wirth H P, Zala G, Flury R, Meyenberger C, Ammann R, Altorfer J
Departement für Innere Medizin, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1994 Apr 16;124(15):615-9.
In a prospective study we examined 20 Helicobacter pylori (HP)-positive duodenal ulcer patients (5 female, 15 male; age 26-70 [mean 43] years), 20 HP-positive patients with non-ulcer dyspepsia (10 female, 10 male; age 26-79 [mean 48] years) and 10 HP-negative patients with non-ulcer dyspepsia (5 female, 5 male; age 21-76 [mean 45] years) during upper GI-endoscopy. HP was detected by histology (H&E, Giemsa), rapid urease test (CLO) and serology (Cobas Core Anti-H. pylori EIA). IgA anti-HP in gastric juice was determined by ELISA. HP-positivity included positivity in all methods, and HP-negativity failure to detect HP-infection by all methods used. Of the 20 duodenal ulcer patients, 10 patients (2 female, 8 male; age 26-70 [mean 42] years) had an endoscopically documented duodenal ulcer at an earlier endoscopy with no current ulcer, 10 patients had florid duodenal ulcer disease at the time of examination. Duodenal ulcer patients compared with non-ulcer dyspepsia patients were tended to have higher serum IgG anti-HP (551 +/- 240 vs. 338 +/- 159 U/ml) and significantly higher gastric juice IgA anti-HP (50.0 +/- 7.3 vs. 26.5 +/- 4.3 relative units). Concentrations of both serum IgG anti-HP and gastric juice IgA anti-HP tended to be higher in patients with positive ulcer history but no present ulcer compared with patients with florid ulcer disease (934 +/- 456 vs. 170 +/- 63 U/ml and 60.0 +/- 8.6 vs. 40.8 +/- 10.4 relative units).(ABSTRACT TRUNCATED AT 250 WORDS)
在一项前瞻性研究中，我们对上消化道内镜检查时的20例幽门螺杆菌（HP）阳性十二指肠溃疡患者（5例女性，15例男性；年龄26 - 70岁[平均43岁]）、20例HP阳性非溃疡性消化不良患者（10例女性，10例男性；年龄26 - 79岁[平均48岁]）以及10例HP阴性非溃疡性消化不良患者（5例女性，5例男性；年龄21 - 76岁[平均45岁]）进行了检查。通过组织学检查（苏木精-伊红染色、吉姆萨染色）、快速尿素酶试验（CLO）和血清学检测（Cobas Core抗幽门螺杆菌酶免疫分析）来检测HP。采用酶联免疫吸附测定法测定胃液中的IgA抗HP。HP阳性包括所有检测方法均呈阳性，HP阴性指使用的所有方法均未检测到HP感染。在20例十二指肠溃疡患者中，10例患者（2例女性，8例男性；年龄26 - 70岁[平均42岁]）在早期内镜检查时有内镜记录的十二指肠溃疡，目前无溃疡，10例患者在检查时患有活动性十二指肠溃疡疾病。与非溃疡性消化不良患者相比，十二指肠溃疡患者的血清IgG抗HP往往更高（551±240 vs. 338±159 U/ml），胃液IgA抗HP显著更高（50.0±7.3 vs. 26.5±4.3相对单位）。与患有活动性溃疡疾病的患者相比，有溃疡病史但目前无溃疡的患者血清IgG抗HP和胃液IgA抗HP浓度往往更高（934±456 vs. 170±63 U/ml以及60.0±8.6 vs. 40.8±10.4相对单位）。（摘要截短于250字）
