Ioachim H L, Pearse A, Keller S E
Cancer Res. 1976 Aug;36(8):2854-62.
Two hemopoietic tumors induced in rats by Gross leukemia virus and dimethylbenz(a)anthracene, respectively, display distinctive and consistent patterns of metastases, the former in the thymus and lymph nodes, the latter in the liver and spleen. To investigate the role of circulatory anatomy in the localization of metastases, 51Cr-labeled cells were injected i.v., and their distribution was followed at various intervals. To explore the influence of immune mechanisms, Gross leukemia virus- and dimethylbenza(a)anthracene-induced leukemic cells as well as a line of antigenically modulated cells were administered to newborn, X-irradiated, and immunologically unresponsive recipients. The circulation of tumor cells through various organs was indiscriminate. The immune response of the host was operative in limiting the local and metastatic tumor growth but not in determining the site of secondary tumors. The conclusion of these experiments was that the selective organ distribution of tumor metastases was solely dependent on intrinsic cellular properties.
分别由格罗斯白血病病毒和二甲基苯并(a)蒽在大鼠体内诱发的两种造血肿瘤，呈现出独特且一致的转移模式，前者转移至胸腺和淋巴结，后者转移至肝脏和脾脏。为了研究循环解剖结构在转移定位中的作用，静脉注射了51Cr标记的细胞，并在不同时间间隔追踪其分布。为了探究免疫机制的影响，将格罗斯白血病病毒和二甲基苯并(a)蒽诱发的白血病细胞以及一系列抗原调节细胞给予新生的、经X射线照射且免疫无反应的受体。肿瘤细胞在各个器官中的循环是无差别的。宿主的免疫反应在限制局部和转移性肿瘤生长方面起作用，但在确定继发性肿瘤的部位方面不起作用。这些实验的结论是，肿瘤转移的选择性器官分布完全取决于内在的细胞特性。
