[Effect of electrostimulation of the hypothalamus on the immunological reactivity of rats with 7,12-dimethylbenz[a]anthracene-induced tumors].

Experiments on Wistar male rats established that electrostimulation of the area of the posterior hypothalamic nuclei 2.5 months after administration of 7,12-dimethylbenz(a)anthracene into the femur muscle restrained to a considerable extent the inhibitory effect of the carcinogen on the immune reactivity. The reactivity was estimated by the amount of antibody-forming and rosette-forming cells in the spleen, thymus, lymph nodes and by the activity of DNA synthesis in the cells of these organs. The effect of hypothalamus electrostimulation may be a determinant in the mechanism of the inhibitory action of chemical carcinogenesis.