Vinnitskiĭ V B, Shevchenko I N, Isaeva E G, Lapteva N A
Eksp Onkol. 1986;8(1):51-4.
Experiments on Wistar male rats established that electrostimulation of the area of the posterior hypothalamic nuclei 2.5 months after administration of 7,12-dimethylbenz(a)anthracene into the femur muscle restrained to a considerable extent the inhibitory effect of the carcinogen on the immune reactivity. The reactivity was estimated by the amount of antibody-forming and rosette-forming cells in the spleen, thymus, lymph nodes and by the activity of DNA synthesis in the cells of these organs. The effect of hypothalamus electrostimulation may be a determinant in the mechanism of the inhibitory action of chemical carcinogenesis.
对雄性Wistar大鼠进行的实验表明，在将7,12 - 二甲基苯并(a)蒽注入股骨肌肉2.5个月后，对下丘脑后核区域进行电刺激，在很大程度上抑制了致癌物对免疫反应性的抑制作用。免疫反应性通过脾脏、胸腺、淋巴结中抗体形成细胞和玫瑰花结形成细胞的数量以及这些器官细胞中DNA合成的活性来评估。下丘脑电刺激的作用可能是化学致癌抑制作用机制中的一个决定因素。
