Versino M, Bergamaschi R, Callieco R, Romani A, Castelnovo G, Beltrami G, Cosi V
Neurological Institute C. Mondino, University of Pavia, Italy.
Acta Neurol Scand. 1994 Feb;89(2):105-10.
We studied saccadic and smooth pursuit eye movements in 24 patients suffering from multiple sclerosis during disease worsening, before and after high-dose 6-methylprednisolone infusions. Quantitative evaluation of saccades was based on amplitude/duration and amplitude/peak velocity relationships, precision (i.e. the ratio of actual to desired saccade amplitude) and the latency, whereas smooth pursuit eye movements were studied using target velocity/performance index relationship. At basal recordings, 22/24 (91.7%) of the patients showed at lest one abnormality. Eleven of the 24 patients (45.8%) showed modification of one or several parameters: improvement in 6 patients, worsening in 2, coexistence of both trends in 3. Latency improvement was the only significant modification when patients were considered as a group. Neurophysiological modifications did not correspond to clinical changes.
我们研究了24例多发性硬化症患者在疾病恶化期间、大剂量6-甲基泼尼松龙输注前后的眼球扫视和平稳跟踪运动。眼球扫视的定量评估基于幅度/持续时间和幅度/峰值速度关系、精确度（即实际扫视幅度与期望扫视幅度之比）以及潜伏期，而平稳跟踪眼球运动则通过目标速度/性能指数关系进行研究。在基础记录时，24例患者中有22例（91.7%）至少表现出一项异常。24例患者中有11例（45.8%）出现一个或多个参数的改变：6例改善，2例恶化，3例同时存在两种趋势。当将患者作为一个整体考虑时，潜伏期改善是唯一显著的改变。神经生理学改变与临床变化不相符。
