采用ProMACE方案第1天/MOPP方案第8天化疗治疗幼淋巴细胞白血病：长期生存病例报告

ProMACE day 1/MOPP day 8 chemotherapy for prolymphocytic leukemia: a case report of prolonged survival.

作者信息

Yuen B H, Godwin J E

机构信息

Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153.

出版信息

Am J Hematol. 1994 Jul;46(3):230-3. doi: 10.1002/ajh.2830460313.

DOI:10.1002/ajh.2830460313

PMID:8192154

Abstract

The treatment result of a case of de novo B-cell prolymphocytic leukemia (B-PLL) is described. The diagnosis was established with histologic, ultrastructural and immunologic studies. The patient was treated with chemotherapy using a total of seven cycles of ProMACE Day 1/MOPP Day 8 lymphoma regimen. Complete remission was achieved after 5 cycles of chemotherapy. The patient remains disease free after a 7-year follow up. This is the first case of PLL being treated with such a regimen and the only case reported achieved such prolonged survival. Results of other treatment modalities are reviewed.

摘要

描述了一例初发B细胞幼淋巴细胞白血病（B-PLL）的治疗结果。通过组织学、超微结构和免疫学研究确诊。患者接受化疗，共使用7个周期的ProMACE第1天/ MOPP第8天淋巴瘤方案。化疗5个周期后达到完全缓解。经过7年随访，患者无疾病生存。这是首例采用该方案治疗的PLL病例，也是唯一报道的获得如此长期生存的病例。回顾了其他治疗方式的结果。