Physicochemical cell damage in relation to lethal amphotericin B action.
作者信息
Beggs W H
机构信息
General Medical Research Service, VA Medical Center, Minneapolis 55417.
出版信息
Antimicrob Agents Chemother. 1994 Feb;38(2):363-4. doi: 10.1128/AAC.38.2.363.
Abstract
A direct relationship between the concentration-dependent rate of amphotericin B-induced K+ release from Candida albicans and the concentration-dependent rate of killing by the drug was established. This relationship together with the observed rapidity of both release and killing action supports the conclusion that the lethal action of amphotericin B is primarily physicochemical in nature.
摘要
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