Abadie C, Hug M, Kübli C, Gains N
Pharma Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Biochem J. 1994 May 1;299 ( Pt 3)(Pt 3):725-30. doi: 10.1042/bj2990725.
Starch that escapes digestion in the small intestine increases the elimination of chenodeoxycholate and its metabolites in the faeces of both mice and hamsters. In contrast, the elimination of cholate and its metabolites is not increased. In vitro, the affinity of starch for chenodeoxycholate is about 90-fold greater than for cholate. beta-Cyclodextrin, which approximates to one turn of the helical structures formed by the 1,4-linked glucose units of starch, shares these properties. It is proposed that these helical structures in starch act as binding sites for bile salts.
在小肠中未被消化的淀粉会增加小鼠和仓鼠粪便中鹅去氧胆酸盐及其代谢产物的排泄。相比之下,胆酸盐及其代谢产物的排泄并未增加。在体外,淀粉对鹅去氧胆酸盐的亲和力比对胆酸盐的亲和力大约高90倍。β-环糊精由淀粉中1,4-连接的葡萄糖单元形成的螺旋结构近似一圈,具有这些特性。有人提出,淀粉中的这些螺旋结构充当胆汁盐的结合位点。