Calamandrei G, Keverne E B
Reparto di Fisiopatologia Comportamentale, Laboratorio di Fisiopatologia, Istituto Superiore di Sanità, Rome, Italy.
Behav Neurosci. 1994 Feb;108(1):113-20. doi: 10.1037//0735-7044.108.1.113.
Immunoreactivity for Fos protein following 30 min of sensory and behavioral experience with foster pups was measured in different brain areas of nulliparous female Balb/c mice who were intact, ovariectomized, or selectively depleted of olfactory bulb noradrenaline. Fos expression was also investigated in intact nulliparous female mice undergoing distal exposure to pup sensory cues. Behavioral interaction with pups increased Fos immunoreactivity in the olfactory areas (anterior olfactory nucleus, piriform cortex, corticomedial amygdala, and entorhinal cortex) as well as in the medial preoptic area, and this occurred regardless of whether females were intact or ovariectomized. Noradrenaline depletion of the olfactory bulb prevented Fos induction in primary olfactory areas, but not in the medial preoptic area, whereas distal exposure to pup cues enhanced Fos expression in the olfactory areas but not in the medial preoptic area.
在与寄养幼崽进行30分钟的感觉和行为体验后，对未生育的雌性Balb/c小鼠的不同脑区进行Fos蛋白免疫反应性测量，这些小鼠分别是完整的、卵巢切除的或选择性去除嗅球去甲肾上腺素的。还对接受幼崽感觉线索远端暴露的完整未生育雌性小鼠的Fos表达进行了研究。与幼崽的行为互动增加了嗅觉区域（前嗅核、梨状皮层、皮质内侧杏仁核和内嗅皮层）以及内侧视前区的Fos免疫反应性，无论雌性小鼠是完整的还是卵巢切除的，这种情况都会发生。嗅球去甲肾上腺素耗竭可阻止初级嗅觉区域的Fos诱导，但不能阻止内侧视前区的Fos诱导，而远端暴露于幼崽线索可增强嗅觉区域的Fos表达，但不能增强内侧视前区的Fos表达。
