Ohtsuka T, Ishikawa H
Department of Dermatology, Gunma University School of Medicine, Maebashi, Japan.
Dermatology. 1994;188(4):286-9. doi: 10.1159/000247167.
Image analysis of videographs of nail fold capillaries was performed in patients with systemic sclerosis (SS), and the capillary patterns were defined by canonical discriminant analysis. Forty-eight of 55 SS patients were significantly differentiated from patients with systemic lupus erythematosus and normal controls. Normal controls and patients with systemic lupus erythematosus showed identical nail fold capillary patterns; in patients with dermatomyositis the pattern was similar to that of SS. The canonical discriminant analysis revealed that only 5 of 55 (9%) SS patients showed a normal capillary pattern. The abnormal capillary pattern in SS patients correlated with microvascular disturbances such as Raynaud's phenomenon, digital pitting scars and low finger temperature. Our results indicate that quantitative analysis of the nail fold capillaries is useful in evaluating the microvascular disturbances in SS patients.
对系统性硬化症（SS）患者的甲襞毛细血管视频图像进行了分析，并通过典型判别分析确定了毛细血管模式。55例SS患者中有48例与系统性红斑狼疮患者和正常对照有显著差异。正常对照和系统性红斑狼疮患者显示出相同的甲襞毛细血管模式；皮肌炎患者的模式与SS患者相似。典型判别分析显示，55例SS患者中只有5例（9%）显示正常的毛细血管模式。SS患者异常的毛细血管模式与微血管紊乱相关，如雷诺现象、指端点状瘢痕和手指温度低。我们的结果表明，甲襞毛细血管的定量分析有助于评估SS患者的微血管紊乱。
