Ohtsuka T, Yamakage A, Tamura T
Department of Dermatology, Gunma University School of Medicine, Maebashi, Japan.
Cutis. 1995 Oct;56(4):215-8.
Videograph images of nail fold capillaries in patients with Raynaud's phenomenon were analyzed, and capillary patterns were defined using standardized canonical discriminant analysis. Of sixty-eight patients with Raynaud's phenomenon, forty-nine (72 percent) showed a systemic sclerosis pattern and nineteen (28 percent) showed a normal pattern. The systemic sclerosis type capillary pattern significantly correlated not only with secondary Raynaud's syndrome but also with sclerodactyly, telangiectasia, and antinuclear antibody. This study confirms the value of nail fold capillary microscopy as a noninvasive technique for the examination of the cutaneous microcirculation in vivo. We should continue to evaluate the patients with Raynaud's phenomenon who showed systemic sclerosis pattern abnormality to determine if these patients would show a progression to systemic sclerosis or not.
对雷诺现象患者的甲襞毛细血管视频图像进行了分析，并使用标准化的典型判别分析来定义毛细血管模式。在68例雷诺现象患者中，49例（72%）表现为系统性硬化模式，19例（28%）表现为正常模式。系统性硬化型毛细血管模式不仅与继发性雷诺综合征显著相关，还与指端硬化、毛细血管扩张和抗核抗体显著相关。本研究证实了甲襞毛细血管显微镜检查作为一种用于体内皮肤微循环检查的非侵入性技术的价值。我们应继续评估表现出系统性硬化模式异常的雷诺现象患者，以确定这些患者是否会进展为系统性硬化。
