Niklasson A, Karlberg P, Albertsson-Wikland K
Department of Paediatrics, University of Göteborg, Sweden.
Acta Paediatr. 1994 Feb;83(2):192-5. doi: 10.1111/j.1651-2227.1994.tb13049.x.
A new model for evaluating leanness/fatness (LeanSDS) in the newborn infant has been used to examine body weight for length in a group of Swedish infants in whom idiopathic growth hormone deficiency (GHD n = 220) was later diagnosed. These infants have earlier been reported to be significantly shorter (median = -0.87 SDS; SDS; standard deviation scores) and lighter (median = -0.60 SDS) in relation to gestational age, than the most recent reference. A group of infants who later developed GHD due to organic etiologies (n = 92) had normal weight and length for gestational age at birth. Using the LeanSDS model (with intercept 0.0 and regression coefficient 0.7) revealed that these idiopathic GHD infants have weight that is normal for their length (mean LeanSDS = 0.11 +/- 0.08 (SEM); n.s.) why the abnormality is a reduced linear growth. These findings also indicate that birth length (linear growth) should be given increased attention when size at birth is evaluated.
一种用于评估新生儿瘦胖程度的新模型（LeanSDS）已被用于检查一组后来被诊断为特发性生长激素缺乏症（GHD，n = 220）的瑞典婴儿的身长体重情况。据报道，与最新参考标准相比，这些婴儿相对于胎龄而言明显更矮（中位数=-0.87 SDS；SDS：标准差分数）且更轻（中位数=-0.60 SDS）。一组因器质性病因后来患上GHD的婴儿（n = 92）出生时的体重和身长与胎龄相符。使用LeanSDS模型（截距为0.0，回归系数为0.7）显示，这些特发性GHD婴儿的体重与其身长相符（平均LeanSDS = 0.11±0.08（SEM）；无显著差异），异常之处在于线性生长减缓。这些发现还表明，在评估出生时的体格大小时，应更多关注出生身长（线性生长）。
