Rodrigues G A, Park M
McGill University, Montreal, Canada.
Curr Opin Genet Dev. 1994 Feb;4(1):15-24. doi: 10.1016/0959-437x(94)90086-8.
Tyrosine kinases comprise the largest group of oncoproteins, a fact that underscores the importance of reversible tyrosine phosphorylation in the regulation of essential cellular functions. Oncogenic activation of tyrosine kinases results in the constitutive activation of what is normally a conditionally regulated enzyme activity. Studies of tyrosine kinase oncoproteins, and a comparison with their corresponding proto-oncogene products, have identified important functional and regulatory domains within these proteins, positive and negative regulators of their enzyme activities and signalling cascades that control cell growth and differentiation.
酪氨酸激酶构成了最大的一类癌蛋白，这一事实凸显了可逆性酪氨酸磷酸化在调节基本细胞功能中的重要性。酪氨酸激酶的致癌激活导致通常受条件调节的酶活性的组成性激活。对酪氨酸激酶癌蛋白的研究以及与它们相应的原癌基因产物的比较，已经确定了这些蛋白内重要的功能和调节结构域、它们酶活性的正负调节因子以及控制细胞生长和分化的信号级联反应。
