蛋白酪氨酸磷酸酶：细胞外和细胞内结构域的特征

Protein tyrosine phosphatases: characterization of extracellular and intracellular domains.

作者信息

Mourey R J, Dixon J E

机构信息

Department of Biological Chemistry, Medical School, Walther Cancer Institute, University of Michigan, Ann Arbor 48109-0606.

出版信息

Curr Opin Genet Dev. 1994 Feb;4(1):31-9. doi: 10.1016/0959-437x(94)90088-4.

DOI:10.1016/0959-437x(94)90088-4

Abstract

Protein tyrosine phosphatases (PTPs) play an important role in the regulation of cell growth and differentiation. With over 30 PTPs identified, the specific functions of these enzymes are now being addressed. The identification of extracellular domain receptor-like PTP interactions and the characterization of intracellular PTP 'targeting' domains represent recent efforts in this pursuit.

摘要

蛋白质酪氨酸磷酸酶（PTPs）在细胞生长和分化的调节中发挥着重要作用。现已鉴定出30多种PTPs，目前正在研究这些酶的具体功能。细胞外结构域受体样PTP相互作用的鉴定以及细胞内PTP“靶向”结构域的表征是这一研究方向的最新成果。

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