McCormick F
Onyx Pharmaceuticals, Richmond, California 94806.
Curr Opin Genet Dev. 1994 Feb;4(1):71-6. doi: 10.1016/0959-437x(94)90093-0.
Over the past year, major advances have been made in understanding the key steps involved in signaling pathways--from receptor tyrosine kinases to ras p21, and on to a cascade of serine/threonine kinases. A chain of specific protein-protein interactions is responsible for signal transduction. Components of the pathway are highly conserved between flies, nematodes and mammals, and constitute a primary signaling device in most cell types.
在过去的一年里，我们在理解信号通路所涉及的关键步骤方面取得了重大进展——从受体酪氨酸激酶到Ras p21，再到一系列丝氨酸/苏氨酸激酶。一系列特定的蛋白质-蛋白质相互作用负责信号转导。该信号通路的组成部分在果蝇、线虫和哺乳动物之间高度保守，并且在大多数细胞类型中构成主要的信号传导装置。
