三元复合因子：生长因子调控的转录激活因子。

Ternary complex factors: growth factor regulated transcriptional activators.

作者信息

Treisman R

机构信息

Transcription Laboratory, Imperial Cancer Research Fund, London, UK.

出版信息

Curr Opin Genet Dev. 1994 Feb;4(1):96-101. doi: 10.1016/0959-437x(94)90097-3.

DOI:10.1016/0959-437x(94)90097-3

PMID:8193547

Abstract

Members of a family of Ets domain proteins, the ternary complex factors (TCFs), are recruited to the c-fos serum response element by interaction with the serum response factor. Recent findings indicate that phosphorylation of TCFs occurs in response to activation of the MAP kinase pathway, and that regulation of TCF activity is an important mechanism by which the serum response element responds to growth factor signals.

摘要

Ets结构域蛋白家族的成员，即三元复合因子（TCFs），通过与血清反应因子相互作用而被招募到c-fos血清反应元件上。最近的研究结果表明，TCFs的磷酸化是对MAP激酶途径激活的反应，并且TCF活性的调节是血清反应元件对生长因子信号作出反应的一种重要机制。