Sinha S, Kumar P, Laloraya M
School of Life Sciences, Indore, India.
Biochem Mol Biol Int. 1993 Dec;31(6):1141-8.
Treatment of spermatozoa with 10 mM caffeine increases the rotational mobility of thiol-containing proteins in a defined micellar micro-environment. This is associated with inhibition of superoxide dismutase activity and augmented superoxide anion radical generation. Increased sperm competence in presence of caffeine in human oligospermia is explained by these observations. Inhibition of cyclic phosphodiesterase by caffeine is suggested to be part of the observed lattice-rearrangement.
用10 mM咖啡因处理精子可增加特定胶束微环境中含硫醇蛋白质的旋转流动性。这与超氧化物歧化酶活性的抑制和超氧阴离子自由基生成的增加有关。这些观察结果解释了咖啡因存在时人类少精子症患者精子受精能力的增强。咖啡因对环磷酸二酯酶的抑制作用被认为是观察到的晶格重排的一部分。
