Nivsarkar M, Patel R Y, Mokal R
Sir H. N. Medical Research Society, Mumbai, India.
Biochem Biophys Res Commun. 1996 Aug 23;225(3):791-5. doi: 10.1006/bbrc.1996.1252.
Low superoxide anion radical levels, low membrane fluidity and high superoxide dismutase activity are some of the defects existing in oligospermia. The phosphodiesterase inhibitor pentoxifylline has been used as a motility stimulant in the treatment of oligospermia in vitro. The mechanism of its action is unclear. Our results show significant inhibition of superoxide dismutase, increase in lipid peroxidation and membrane fluidity after pentoxifylline treatment. A biophysical modulation of the sperm membrane by an oxyradical mechanism in oligospermia is discussed.
