基底样支气管癌。一个预后较差的组织学类型。
Basaloid bronchial carcinoma. A histologic group with a poor prognosis.
作者信息
Moro D, Brichon P Y, Brambilla E, Veale D, Labat F, Brambilla C
机构信息
Department of Respiratory Medicine, Hopital A. Michallon, Grenoble, France.
出版信息
Cancer. 1994 Jun 1;73(11):2734-9. doi: 10.1002/1097-0142(19940601)73:11<2734::aid-cncr2820731114>3.0.co;2-4.
BACKGROUND
Basal cell carcinomas (BCCs) have been described in various locations, such as skin, anal canal, tongue, larynx, and recently, the lungs. These tumors seem to have a poor prognosis.
METHODS
A series of 115 surgically resected lung tumors, previously classified as poorly or undifferentiated carcinoma, were reviewed retrospectively. From these, 37 cases were reclassified as BCCs and were compared in terms of clinical features and survival, with 40 cases reclassified as poorly differentiated squamous cell (PDSC) carcinoma of the lung.
RESULTS
There was no difference between the groups regarding age, clinical presentation, pattern of relapse, and cause of death. Median and overall survival were different between the two groups, especially for Stage I and II patients: 5-year actuarial survival in the BCC group was 15% and in the PDSC group 47% (P = 0.004).
CONCLUSIONS
This subset of non-small cell lung cancer (NSCLC) has a worse prognosis than other NSCLC, and this should be considered in survival studies and new treatment trials.
背景
基底细胞癌（BCC）已在多个部位被发现，如皮肤、肛管、舌头、喉部，最近在肺部也有发现。这些肿瘤似乎预后较差。
方法
回顾性分析了一系列115例手术切除的肺肿瘤，这些肿瘤先前被分类为低分化或未分化癌。其中，37例被重新分类为BCC，并在临床特征和生存率方面与40例重新分类为肺低分化鳞状细胞（PDSC）癌的病例进行比较。
结果
两组在年龄、临床表现、复发模式和死亡原因方面没有差异。两组的中位生存期和总生存期不同，尤其是I期和II期患者：BCC组的5年精算生存率为15%，PDSC组为47%（P = 0.004）。
结论
这种非小细胞肺癌（NSCLC）亚型的预后比其他NSCLC更差，在生存研究和新的治疗试验中应予以考虑。
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